By American College of Chest Physicians
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Impact of pregnancy on women with CF. Chest 2006; 129:706– 711 Concern exists about the impact of pregnancy on the health of women with CF. This study suggests that women with CF who become pregnant experience similar respiratory and health trends compared to nonpregnant women with CF. However, pregnant women used a greater number of therapies and received more intense monitoring of their health. Moss RB, Rodman D, Spencer LT, et al. Repeated adeno-associated virus serotype 2 aerosol-mediated CF trans-membrane regulator gene transfer to the lungs of patients with CF: a multicenter, double-blind, placebocontrolled trial.
Although some patients with PE likely can also be treated as outpatients, the data for this population are less robust. Recently, prognostic scores in patients with acute PE have been developed and validated and may help to accurately identify low-risk patients. Patients with acute VTE require prolonged anticoagulation to prevent extension and recurrence. The current guidelines recommend 3 months of therapy for patients in whom thrombosis develops in the setting of documented transient risk factors.
Ordinary physical activity does not cause undue dyspnea or fatigue, chest pain, or near syncope. Patients with PH resulting in slight limitation of physical activity. These patients are comfortable at rest, but ordinary physical activity causes undue dyspnea or fatigue, chest pain, or near syncope. Patients with PH resulting in marked limitation of physical activity. These patients are comfortable at rest, but less than ordinary physical activity causes undue dyspnea or fatigue, chest pain, or near syncope.