By Lodovico Balducci, William B. Ershler, John M. Bennett
Anemia within the aged has been appropriately outlined because the silent epidemic, representing three million humans within the usa elderly sixty five years and older. prevalence and occurrence of this raise with age. It differs in its etiology, pathogenesis and therapy from anemia in young children and more youthful adults. Anemia is linked to diminished survival, elevated danger of useful dependence and hospitalization, elevated hazard of congestive middle failure and level renal sickness and cognitive problems. nearly 70% of anemia in older members is reversible.
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Anι´a BJ, Suman VJ, Fairbanks VF, Rademacher DM, Melton LJ 3rd: Incidence of anemia in older people: an epidemiologic study in a well defined population. J Am Geriatr Soc. 1997 Jul;45:825–31 9. Lipsitz LA: Physiological complexity, aging, and the path to frailty. Sci Aging Knowledge Environ. 2004 Apr 21;2004(16):pe16. Review 10. Walston A, Headley EC, Ferrucci L et al: Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults.
Correction of anemia may break this vicious circle and delay the complications of aging. Loss of entropy and fractality is reflected in the declining function of several organ systems (12). Of clinical relevance are: ● A progressive decline in glomerular filtration rate (GFR) that is almost universal and may be associated with reduced production of erythrpopoietin; Inflammatory cytokines; Chronic diseases; Environmental injuries Anemia Functional dependence Fig. 1. Anemia and aging: a vicious circle 23 2.
In addition to anemia, B12 deficiency may be a cause of neurologic disorders including dementia, and posterior column lesions. Seemingly, the main cause of iron deficiency is chronic bleeding, from cancer, diverticuli, or angiodysplasia. In older age iron deficiency may have other causes, including decreased absorption of iron, due to gastric achylia, and to increased circulating concentrations of hepcidin. Hepcidin prevents the absorption of iron from the duodenum, and is a protein synthesized in the liver, whose production is stimulated by IL-6 (37) A recently recognized cause of iron deficiency is H Pylori gastritis (38).